Action Mechanism of using Generic Clomid (Clomiphene):
As mentioned above, ovulatory disorders can cause serious fertility problems. There are many pharmacologic agents being used to induce ovulation and clomiphene citrate or clomid is one of them. Among them are selective estrogen receptor modulators, urinary recombinant gonadotropins, insulin sensitizing constituents, aromatase inhibitors and so on. Clomiphene citrate or clomid has been preferred as a first-line of treatment due to its easier availability, affordability and relative lack of side effects. The success rate of Clomid (Clomiphene) is also high as it has been able to induce ovulation in many amenorrheic women.
When you buy clomid (Clomiphene), you get access to clomiphene citrate which has been reclassified as one of the best selective estrogen receptor modulators. It is both estrogen agonist as well as antagonist. The advantage is that its agonist properties come to the fore only when the level of endogenous estrogen is low and overall, it is the antagonistic properties that prevail.
This causes a drop in the estrogen receptors at the hypothalamus and pituitary glands. Normally it is the negative feedback of estrogen that causes issues. At this time, the secretion of GnRH goes up and the production of the FSH or follicle stimulating hormone also increases. That in turn stimulates release of the necessary hormones for ovulation.
The use of clomid (clomiphene) has been found to be very effective in women who either do not ovulate or have irregular ovulation. But for the medicine to be fully helpful, the estrogen as well as the pituitary gland functions of the subject need to be normal and her male partner too should be fertile enough to release sperms that can fertilize the egg.
The clomid or clomiphene challenge test is also used to check the ovulation and the quality of eggs. When clomid is administered during the menstrual cycle, clomid (clomiphene) raises the FSH level but the next day there is a drop back to normal levels. This indicates that the ovarian reserve is normal. The administration of clomid (clomiphene) is across 4-6 monthly cycles. It may sometimes take more cycles in order to determine just what the right dose for ovulation is. Beyond 6 cycles, if there is no improvement, the chances are that the treatment is not successful.